Brand names of some acetaminophen-based medications are Tylenol, Panadol, Māpap, FeverAll, and Tempra. Many formulations with different concentrations of acetaminophen are available, including liquid suspensions, tablets, capsules, and rectal suppositories with a paraffin base. Today, acetaminophen (chemical name N-acetyl- p-aminophenol, or APAP known as paracetamol in most countries outside of the United States and Canada) is readily accessible and is an ingredient in more than 200 over-the-counter and prescription medications, either as a single agent or in combination with other pharmaceuticals. 1 The increased use of acetaminophen since the 1960s stems from the association of aspirin-containing medications with the occurrence of Reye syndrome in children. consumers purchased more than 28 billion doses of products containing acetaminophen. Key words: acetaminophen, paracetamol, N-acetyl- p-aminophenol (APAP), acetaminophen-induced hepatotoxicity, N-acetyl- p-benzoquinone imine (NAPQI), glutathione, sulfation, liver transaminases, centrilobular hepatic necrosis, Rumack-Matthew nomogram, N-acetylcysteine (NAC)Īcetaminophen is the most commonly used analgesic–antipyretic medication given to children in the United States and worldwide. This article reviews the pathophysiology of acetaminophen metabolism, the clinical and diagnostic clues of an acute overdose, differential diagnoses, and management approaches including the use of the antidote, N-acetylcysteine (NAC), for acute acetaminophen overdose and toxicity in pediatric patients. ABSTRACT: Acetaminophen is the most commonly used pain medication in the United States, and its ubiquity results in its being one of the most frequently implicated drugs in childhood poisonings.

Acetaminophen antidote